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872-50-4

  • Product Name:N-METHYL-PYRROLIDONE
  • Molecular Formula:C5H9NO
  • Purity:99%
  • Appearance:colourless or light yellow liquid with an amine odour
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Product Details

Appearance:colourless or light yellow liquid with an amine odour

Purity:99%

872-50-4 Name

Name

N-METHYL-PYRROLIDONE

Synonym

N-Methyl-2-pyrrolidone;M-PYROL(R);1-Methyl-2-pyrrolidinone( 99.5%, HyDry, Water≤50 ppm (by K.F.));1-Methyl-2-pyrrolidinone( 99.5%, HyDry, with molecular sieves, Water≤50 ppm (by K.F.));N-Methyl-2-pyrrolidone Manufacturer;1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT (ACS);1-Methyl-2-pyrrolidinone 872-50-4 NMP N-Methyl-2-pyrrolidinone;N-Methyl-2-pyrrolidinone 872-50-4 NMP;1-METHYL-2-PYRROLIDINONE

 

872-50-4 Biological Activity

Description

N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an organic polar solvent. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals[1][2].

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References

[1]. Jing Wang, et al. Nitrate stimulation of N-Methylpyrrolidone biodegradation by Paracoccus pantotrophus: Metabolite mechanism and Genomic characterization. Bioresour Technol. 2019 Dec;294:122185.

[2]. Claudia Julieta Solís-González, et al. Novel Metabolic Pathway for N-Methylpyrrolidone Degradation in Alicycliphilus sp. Strain BQ1. Appl Environ Microbiol. 2017 Dec 15;84(1):e02136-17.

 

872-50-4 Chemical & Physical Properties

Melting point 

−24 °C(lit.)

Boiling point

202.0±0.0 °C at 760 mmHg

Density

1.0±0.1 g/cm3

Molecular Formula

C5H9NO

Molecular Weight

99.131

Flash Point

86.1±0.0 °C

PSA

20.31000

LogP

-0.40

Exact Mass

99.068413

Vapour density

3.4 (vs air)

Vapour Pressure

0.3±0.4 mmHg at 25°C

Index of Refraction

1.470

Stability

Stable, but decomposes upon exposure to light. Combustible. Incompatible with strong oxidizing agents, strong acids, reducing agents, bases.

Water Solubility

>=10 g/100 mL at 20 ºC

 

872-50-4 Description

N-Methyl-2-Pyrrolidone (NMP) is a powerful, aprotic solvent with high solvency, and low volatility. This colorless, high boiling, high flash point and low vapor pressure liquid carries a mild amine-like odor. NMP has high chemical and thermal stability and is completely miscible with water at all temperatures. NMP can serve as a co-solvent with water, alcohols, glycol ethers, ketones, and aromatic/chlorinated hydrocarbons. NMP is both recyclable by distillation and readily biodegradable. NMP is not found on the Hazardous Air Pollutants (HAPs) list of the 1990 Clean Air Act Amendments.

 

872-50-4 Uses

  1. N-Methyl-2-pyrrolidone is a polar solvent that is used in organic chemistry and polymer chemistry. Large scale applications include the recovery and purification of acetylenes, olefins, and diolefins, gas purification, and aromatics extraction from feedstocks.N-Methyl-2-pyrrolidone is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.
  2. Solvent for high-temperature resins; petrochemical processing, in the microelectronics fabrication industry, dyes and pigments, industrial and domestic cleaning compounds; agricultural and pharmaceutical formulations
  3. N-Methyl-2-pyrrolidone, is useful for spectrophotometry, chromatography and ICP-MS detection.

 

872-50-4 Production Methods

N-Methyl-2-pyrrolidone is manufactured by the reaction of buytrolactone with methylamine (Hawley 1977). Other processes include preparation by hydrogenation of solutions of maleic or succinic acids with methylamine (Hort and Anderson 1982). Manufacturers of this chemical include Lachat Chemical, Inc, Mequon, Wisconsin and GAF Corporation, Covert City, California.

 

872-50-4 Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by skin contact. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Combustible when exposed to heat, open flame, or powerful oxidizers. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.