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Appearance:white powder
Purity:99%
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25086-89-9 Name |
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Name |
Copovidone/VA64 |
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Synonym |
Poly(1-vinylpyrrolidone-co-vinyl acetate);Aceticacid,ethenylester,polymerwith1-ethenyl-2-pyrrolidinone;aceticacidethenylester,polymerwith1-ethenyl-2-pyrrolidinone;aceticacidethenylestercopolymerwith1-ethenyl-2-pyrrolidinone;aceticacidvinylester,polymerwith1-vinyl-2-pyrrolidinone;gantrons860;i535;i635;i735 |
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25086-89-9 Chemical & Physical Properties |
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Boiling point |
536.7±50.0 °C at 760 mmHg |
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Density |
1.0±0.1 g/cm3 |
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Molecular Formula |
(C6H9NO.C4H6O2)x |
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Molecular Weight |
486.726 |
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Flash Point |
254.7±28.5 °C |
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PSA |
46.61000 |
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LogP |
9.76 |
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Exact Mass |
486.370911 |
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Vapour Pressure |
0.0±1.4 mmHg at 25°C |
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Index of Refraction |
1.517 |
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Stability |
Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents. |
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25086-89-9 Description |
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Copovidone is a white to yellowish-white amorphous powder. It is typically spray-dried with a relatively fine particle size. It has a slight odor and a faint taste. ～1:2.4 mole ratio of VP:VA |
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25086-89-9 Production Methods |
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Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water. |
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25086-89-9 Uses |
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Copovidone is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches. |
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25086-89-9 Pharmaceutical Applications |
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Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier. |
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25086-89-9 Safety Profile |
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Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx. |
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25086-89-9 Safety |
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Copovidone is used widely in pharmaceutical formulations and is generally regarded as nontoxic. However, it is moderately toxic by ingestion, producing gastric disturbances. It has no irritating or sensitizing effects on the skin. A study was conducted to look at the carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs. The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested. LD50 (rat, oral): >0.63 g/kg |
