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pd_productuse:Povidone is one of the most important excipients in the worldwide for pharmaceutical industry,whatever for human health care products and animal health care products.Which used as:1)Binder for tables,capsule,2)Sugar coatings and films,3)Thickening agent,4)Solubility Improver for poorly soluble drugs,5)Bioavailability Enhancer for drug’s active ingredients,6)Pore-forming for membrane products.
Purity:99%
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9003-39-8 Name |
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Name |
Povidone K17 |
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Synonym |
toxobin;vinisil;vinylpyrrolidinonepolymer;vinylpyrrolidonepolymer;PVP K30 USP24;PVP K120;K30 PVP K30;K 30 POVIDONE K 30 BP/USP |
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9003-39-8 Biological Activity |
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Description |
Polyvinylpyrrolidone is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds. |
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Related Catalog |
Signaling Pathways >> Others >> Others Research Areas >> Infection Biochemical Assay Reagents |
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In Vivo |
Goldfishes which are treated with salt have significantly lower mucus weights at 25 h. Goldfishes treated with Polyvinylpyrrolidone (PVP) have significantly higher mucus weights at 25 h. Koi treated with salt and Polyvinylpyrrolidone (PVP) has significantly lower mucus weight at 1 and 25 h. Control koi has significantly higher mucus at 25 h. At the end of 2 weeks, it is determined that the three koi treated with salt and Polyvinylpyrrolidone(PVP) remain healthy and show a higher degree of healing than other treatment koi and the control group[1]. |
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Animal Admin |
Each fish within a tank serves as a replicate. Treatments are designated as Polyvinylpyrrolidone (at a dose of 10 mL/10 gallon) and saline/salt at 3g/L. A control group that does not receive any chemical is also included in the study. All fishes from each treatment group are sampled at 0 min, 15 min, 1 h, 4 h and 25 h. At each time interval, all fishes from each treatment group are anaesthetized using buffered tricaine methanesulfonate, weighed, and slime is scraped from one 1 cm2 area over the epaxial musculature using a preweighed plastic coverslip[1]. |
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References |
[1]. Shivappa RB, et al. Laboratory evaluation of different formulations of Stress Coat? for slime production in goldfish (Carassius auratus) and koi (Cyprinus carpio). PeerJ. 2017 Sep 6;5:e3759. |
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9003-39-8 Chemical & Physical Properties |
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Melting point |
130ºC |
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Boiling point |
217.6ºC at 760 mmHg |
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Density |
1.144g/cm3 |
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Molecular Formula |
(C6H9NO)n |
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Molecular Weight |
111.1418 (monomer) |
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Flash Point |
93.9ºC |
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PSA |
20.31000 |
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LogP |
0.69020 |
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Storage condition |
Store at RT. |
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Water Solubility |
H2O: soluble100mg/mL |
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9003-39-8 Chemical Properties |
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It is the cross-linked homopolymer of pure vinylpyrrolidone. It is hygroscopic and free-flowing white or off-white powder. It has a slight foul smell. It is insoluble in common solvents such as water, ethanol and ether. So its molecule weight range can’t be measured. However, PVP has ability to form complex with various kinds of substances (such as “Hu” class substance which can lead to the discoloration of a variety of wines and beverages discoloration). Also it is easily to be removed after filtration because of its insolubility. |
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9003-39-8 Uses |
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Polyvinylpyrrolidone is used as an adhesive in glue sticks; an emulsifier and a disintegrant for solution polymerization; an additive to Doro's RNA extraction buffer; as a liquid-phase dispersion enhancing agent in diffusion-ordered spectroscopy (DOSY) NMR and as a thickening agent in tooth whitening gels. It finds use in personal care products like shampoos and toothpastes, in ink for inkjet printers as well as in contact lens solutions. It is used as a food additive and in the wine industry as a fining agent for white wine. It is used as a capping agent to synthesize silver nanowires through a polyol process. Polyvinylpyrrolidone has been used: To perform intracytoplasmic sperm injection procedure; In the preparation of endophyte coating agent mixture, to coat creeping bentgrass seed; As a component of prehybridization solution. |
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9003-39-8 Preparation |
N -Vinylpyrrolidone is water-soluble and is usually polymerized in aqueous solution at about 50°C with ammonia and hydrogen peroxide. The polymer is also water-soluble and is isolated by spray-drying. Commercial grades of polyvinylpyrrolidone (PVP) have average molecular weights (Mv) ranging from about 10000 up to 360000. The largest use of polyvinylpyrrolidone is in cosmetic formulations, especially hair lacquers. In the latter applications, polyvinylpyrrolidone is the preferred film-former on account of good adhesion to hair, lustre of the film and ease of removal on washing. The polymer is also used as a binder in pharmaceutical tablets. Polyvinylpyrrolidone also finds use in the textile industry, particularly in colour stripping operations, where the great affinity of the polymer for dyestuffs is utilized. An interesting application of polyvinylpyrrolidone is in aqueous solution as a blood plasma substitute; such material was extensively used in Germany during the Second World War. |
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World Health Organization (WHO) |
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Polyvidone, a polymer of vinylpyrrolidinone, is an excipient used as a suspending and dispersing agent. Injectable preparations containing polymers with a molecular weight in the order of 12,000 have caused painful local granulomatous lesions. This has led to the withdrawal of polyvidone from such preparations in some countries. Polyvidone was formerly also used as a plasma expander but, because it was sequestered within the liver and spleen, this use has been discontinued. However, it remains widely used as a vehicle for ophthalmic preparations, and as the major component of artificial tears. |
